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How long can you use clotrimazole? How long you use clotrimazole for depends on the type of infection you have. It's best to use it for at least 2 weeks, even if all signs of the infection have gone, to stop it from coming back. It can be used for up to 4 weeks if needed. Apply clotrimazole to the affected area 2 to 3 times a day.
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